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Originally just about Vitamin U, I’ve recently added a section on Zinc-carnosine as well. Both Vitamin U and Zinc-carnosine help to rebuild and protect gastric mucosal lining. Whether dealing with H. pylori, digestive pain, full blown ulcers or trying to seal leaky gut, these two supplements have been well-studied and both have great reviews from patients.
Stomach Pain
I personally went years on a gut healing protocol without knowing the cause or solution for my stomach aches. They usually felt localized, a bit of sharp pain in one spot. Sometimes I could trace them to eating a big meal or certain foods. Other times I was at a loss for the cause.
I discovered liquid aloe (great stuff!) to soothe the pain, which helped the symptom. But I wanted to eliminate the problem completely in my goal for overall wellness.
Of course any kind of gnawing pain has the potential to be an ulcer — or worse.
Here’s what I finally learned and implemented … to soothe and heal my leaky gut.
What is Vitamin U?
Vitamin U, or methylmethionine sulfonium chloride (MMSC), is found in raw cabbage juice. It’s been used in medical studies for healing peptic ulcers, providing rapid relief from pain as well as healing to the compromised tissue. The first medical study of this kind was done back in 1949 with shockingly excellent results. Many of these patients couldn’t have surgery; but a quart of cabbage juice each day for 2-3 weeks, or dehydrated cabbage juice, healed them! (source)
Of the 92 patients with ulcer pain 86 of them were pain-free within 3.92 days!, on average. That’s a fast 95.9% success rate. 81% of them were pain-free within the first week.
These patients were spared long-term drug use, the standard medical treatment. This 1949 study concluded that vitamin U treatment was more effective than medications for the same condition, as it prompted a healing response in the body that lasted, unlike medications.
Zinc-Carnosine for Leaky Gut
Zinc-carnosine is another supplement to consider — with great clinical studies and patient reviews. The compound supports a healthy gastrointestinal lining and relieves mild gastric pains. Clinically tested, Zinc-carnosine protects and stabilizes the gastric and intestinal mucosal lining with “impressive results”. (source)
Zinc-carnosine is a man-produced derivative of carnosine in which a zinc ion and carnosine are bound in a 1-to-1 ratio to create a chelate compound. The chelate has been used in Japan since 1994 for gastric ulcers, gastritis and dyspepsia symptoms. Studies show that the combination chelate is three times more effective than the individual ingredients alone. (source)
This supplement supports a healthy microbial balance and helps to seal intestinal permeability. Patients who struggle with SIBO, histamine intolerance, ulcers, reflux, H. pylori and heartburn have all seen improvement.
How to recover from Leaky Gut with Vitamin U and Zinc-carnosine
Under ordinary circumstances, in a healthy gut, the stomach has a mucosal lining which protects it from the acid-pepsin digestive environment.
What is vitamin U doing? It’s providing this resistance, this protection. Vitamin U is high in L-glutamine and contains a unique form of methionine, an essential amino acid, which stimulates the production of mucous. It works as an antioxidant and, converted in the body, also serves as a methyl donor. (source and source) Vitamin U has a beneficial effect on the liver and even has a role in producing butyrate, that short chain fatty acid that contributes to a healthy colon. (source)
Vitamin U’s biological effects are not fully understood, and more clinical trials are warranted to better understand its uses and benefits.
Zinc-carnosine has been shown to prevent and treat inflammation. Data indicates that Zinc-carnosine may improve the health of epithelial cells and help to create the tight junction structure needed to seal leaky gut. (source)
Vitamin U and Zinc-carnosine supplement options
Look for a good vitamin U supplement with Methylmethionine Sulfonium and Zinc-carnosine (like this one); it contains mastic gum (for overcoming an H. pylori infection) and deglycerized licorice, as well as zinc for inflammation, all of which I discuss here, or one with just Zinc-carnosine (like this one).
These supplements are excellent for patients who find they need to metaphorically go back one step. Perhaps you’re unable to tolerate digestive aids like Betaine HCl or digestive bitters; they’re too strong, causing pain or other uncomfortable symptoms.
Perhaps you’re discouraged as you can’t make progress on a wellness diet, or you’re just starting out on GAPS, SCD, AIP or Keto.
If you feel fragile inside or that you need to make progress but it’s not happening, vitamin U and/or Zinc-carnosine may be JUST what you need.
If it’s true that all health starts in the gut, these supplements help to provide the mucosal lining that is fundamental to both healing and preventing food sensitivities. They shield and cause healing in the gut lining. And the results can be fast.
I didn’t have a full-blown ulcer and for me relief was immediate and prophylactic; I just don’t get stomach aches anymore.
When you feel the timing is right, try adding in digestive bitters, like this one, which also helps to detoxify the liver. First consult your functional medical doctor or naturopath to be sure this course of action is right for your body.
Is this you? I’d love to hear your experiences with vitamin U or Zinc-carnosine. Let me know in the comments how they’ve worked for you.
Fun Fact
Vitamin U, or methylmethionine sulfonium chloride (MMSC), got its name from the Latin ulcus meaning sore or ulcer. The U essentially stands for ulcer!
Vitamin U for heart disease and kidney health
In 1979 another study was done with vitamin U and rats, which showed a benefit to kidney function and relief for those with hyperlipidemia, or high levels of fat in the blood. (source) While vitamin U thus showed itself to reduce the risk of heart disease, this line of study deserves further research.
Hyperlipidemia currently affects 71 million Americans. Dietary change, reducing stress and improving lifestyle, alongside vitamin U consumption and other supplements (milk thistle, garlic and several others), are recommended steps for reversing this dangerous diagnosis. These are all great alternatives to statins which are commonly prescribed, ineffective and laden with side effects.
Emily @ Recipes to Nourish says
Very cool Megan! I had no clue about this. It sounds like it’s super helpful, especially when tummy pain is involved.
Healthcare Maquis says
I have never heard of this, and now I am intrigued.
linda spiker says
Once again I learn something new from you. I have never heard of vitamin U before. Now my interesest is piqued!
thefoodhunter says
very interesting and good to know. Thank you for sharing.
Jess says
Oh wow…I’ve read a little bit about vitamin U, but you have given us some really thorough information here. Thank you for sharing! I love that you’ve shared your favorite brand, too. I think I’ll grab a bottle and give it a go. Thanks!
Megan Stevens says
Great, Jess! 🙂
Eileen - Wellness and Workouts says
Sadly this is me. I have started and re-started GAPS more times than I would like. I definitely have signs of low stomach acid. And taking hcl formulas eventually causes stomach pain for me.
I recently learned that I have had chronic fluoride poisoning due to our well water, (we tested for many contaminants, but never suspected fluoride might occur naturally in our water, especially at ten times the supposed “safe” level) so my stomach is super prone to stomach aches now from all the damage.
Thank you so much for emailing me about this article! My poor health has kept me less active in the circles where I normally interact with you. I hope you will email your list more often, I love your work, you consistently provide such helpful information!
Megan Stevens says
Oh Eileen, I’m so sorry to hear you’ve had poor health lately!! How nice to hear from you, and thank you for your kinds words and encouragement! I’m so excited for you to try this supplement?! I hope it’s a huge boon for you!! 🙂 🙂 Let me know. You should feel the benefit quickly. Many hugs and love for your own encouragement and improvement and hope!!! xoxo!
Eileen - Wellness and Workouts says
Thanks, Megan! Looks like I have used this before, but was ingesting fluoride during and after. Maybe now it will work better for me…
Megan Stevens says
Great, I will hope that for you!
@SBKK4 says
Is this to be continued after the pain subsists?
Megan Stevens says
Yes, I think of it as a companion supplement to a healing diet. So just as we do healing diets for years to heal gut lining and promote a better flora ecosystem, it seems wise to continue with the supplement for perhaps 6 months after symptoms have abated. This is the route I’m taking personally. You can weigh what you consider best for your body and circumstances.
Deborah says
Would eating sauteed cabbage produce the same results as the Gastrazyme?
Megan says
No, cooked cabbage does not have the same effect. But small amounts of sauerkraut juice will be helpful for some.
Deborah says
Would these be a useful treatment for h.pylori?
Megan says
Hi Deborah, both of these supplements have been studied for use with H. pylori and found to be helpful. Customer reviews on these products for H. pylori are also very good.
Clair says
I noticed that the supplment in the link you posted has high levels of vitamin A. I had read from your blog the dangers of vitamin A. Do you feel the benefits from vit U outway the possible toxitcy of Vitamin A in this product?
Megan says
Hi Clair, thank you for your comment. I hadn’t updated this post since learning about the dangers of vitamin A. I just updated the product I link to to one that does not contain vitamin A. I’m so glad you mentioned it. 🙂
Deborah says
The link that is posted for the vitamin U supplement only takes me to the Mayo Clinic website. What is the correct link to the new vitamin U supplement you recommend? Thank you, Megan.
Megan says
Hi Deborah, unfortunately that product no longer exists (and I’m not sure how the link switched, but thank you for letting me know). I have updated the post to link to this product: https://amzn.to/3diyeKt
Deborah says
Thank you Megan. Unfortunately, I have tried the Gastromend, but I cannot tolerate it due to the form of vitamin C. It really irritates my bladder because I also have IC which I am working on. I have eliminated fruits and it has helped somewhat. I also have h-pylori but I have difficulty with a lot of supplements due to my IC. I’m afraid I might have to go to a pharmaceutical for the h-pylori. I have also tried Nutricology’s Mastic Gum. It seems very stubborn to get rid of.
Megan says
Hi Deborah, I’m so sorry. Have you tried high doses of colloidal silver? I buy it from a local farmer who makes her own, which makes it affordable. It is my favorite natural remedy of all time. The brand I trust (for the small particle size), if you choose to buy it, is Sovereign, here: https://amzn.to/34RJA43. If you end up loving it and feel you’re improving, you could consider getting a machine to make your own. I would, if I didn’t have the affordable source.
Deborah says
Thank you Megan. Colloidal Silver can get rid of h-pylori?
Sana Ahmed says
Hi Are there any vitamin u supplements for kids? my daughter is 3 with digestive trouble.
Megan says
Hi Sana, you might consider a small amount of probiotic sauerkraut juice for the vitamin U and supplementing her diet with collagen or bone broth, so she gets the gentle vitamin C, U and gut-building collagen.
Naomi says
Most of the recipes for making raw cabbage juice call for adding other veggies/fruits to the mix for better tasting juice. Are you speaking about cabbage only, and about how much cabbage would I need to make a quart of juice? A quart per day is a lot of juice. I would be hard-pressed to eat any food after drinking that much juice, even in spurts throughout the day. My gut seems not to be tolerating food at all, and I’m beginning to really hate food. Everything makes me bloat instantly, even water. I’ve recently begun taking Dr. Mercola’s bitters, and awaiting an order of Ox Bile to arrive. I have no gall bladder, and am beginning to connect that with the IBS symptoms I’ve been suffering. I think I will order the gentian and save at least that much money to make my own bitters.
Megan says
Hi Naomi, great to hear about the digestive aids you’ve ordered and are considering. Yes, that method of cabbage juice was the original approach, but it no longer seems practical. I’d also look at low-FODMAP for yourself, considering the bloating, and even rule out SIBO. I’d keep searching for the right diet for yourself, as that makes the most difference, combined with digestive aids. I’ve personally found the low-A diet to be the most helpful: https://eatbeautiful.net/vitamin-a-detox-diet-free-printable-food-lists-avoid-eat-toxicity/