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Creatine is one of the most researched sports supplements available, with evidence supporting benefits for strength, power, exercise performance and muscle mass. But do we really need the large “loading phase” commonly recommended when beginning creatine?
Research suggests we don’t. For those who aren’t concerned with saturating their muscles as quickly as possible, a smaller daily dose offers a simpler, more conservative approach — that’s gentler to the kidneys.
You Don’t Need to Load Creatine
The traditional creatine protocol begins with approximately 20 grams per day for 5–7 days, usually divided into four 5-gram doses, followed by a maintenance dose of 3–5 grams daily.
The purpose of loading isn’t to make creatine work better long-term. It simply gets creatine into the muscles faster.
The International Society of Sports Nutrition (ISSN) has specifically stated that creatine does not have to be loaded. Earlier ISSN guidance reported that taking just 2–3 grams daily gradually increases muscle creatine stores over approximately 3–4 weeks.
More recent recommendations generally use 3–5 grams daily without loading, which has a larger body of research behind it.
The National Academy of Sports Medicine (NASM) likewise calls loading optional, stating that 3–5 grams daily without loading is ultimately just as effective for increasing muscle creatine — it simply takes about 28 days instead of about one week.
The NIH Office of Dietary Supplements also recognizes a no-loading approach, describing approximately 3–6 grams daily for 3–4 weeks as an alternative.
What About Just 2 to 2.5 Grams Daily?
Interestingly, research suggests benefits can occur with even less than the usual recommended maintenance dose.
I learned about this lower dose based on Dr. Garrett Smith’s advice in many of his YouTube videos (48:00 mark). His concern centers around kidney health. We are essentially overusing this filter to process huge amounts of water and creatine, placing a heavy burden on these precious organs. In the long run, it doesn’t make sense to put such a heavy load on the kidneys when we can still get great gains from a more balanced approach.
Studies involving competitive soccer players have used approximately 0.03 grams of creatine per kilogram of body weight daily. Depending on the study population, this worked out to only about 2.0–2.3 grams per day, yet researchers still reported improvements in measures of repeated high-intensity exercise performance.
Thus, 2–2.5 grams daily is a reasonable lower-dose strategy, particularly for someone who doesn’t need rapid muscle saturation.
While 3–5 grams daily has considerably more research supporting it, researchers are not motivated by investigations into kidney health.
Individual needs may vary according to body size, muscle mass, diet and baseline creatine stores — but, for our own son who is 6’4″ tall, we are still choosing to limit his daily intake to 2–2.5 grams! He started his intake this week, so we’re curious what he’ll experience in 28 days. (I’ll update the post with our results.)
We’re choosing to boost the effectiveness of his creatine dose by using it alongside pure glutamic acid (also known as pure MSG, around which a lot of confusion exists).
Read more about this approach here.
How Much Water Should You Drink?
Surprisingly, there is no scientifically established amount of extra water required per gram of creatine.
Creatine can conveniently be mixed into about 8–12 ounces of water, but that amount isn’t necessary for kidney protection. Continue drinking adequately throughout the day according to thirst, activity level, temperature and individual needs.
Signs of inadequate hydration include thirst, dry mouth, darker urine, decreased urination, headache, fatigue or dizziness rather than isolated kidney pain.
While high doses of creatine come with warnings to drink almost two gallons of water a day, lower doses of creatine need only be guided by one’s own thirst.
For our son, we have him drink Potassium Water each day to help keep his electrolytes balanced and support proper hydration. Potassium plays an important role in maintaining the balance of intracellular and extracellular sodium, so it indirectly supports creatine uptake.
Should Creatine Be Taken With Food?
Creatine doesn’t have to be taken with food.
Taking it with a meal may improve stomach tolerance, and carbohydrate or carbohydrate plus protein can increase creatine retention because of the resulting insulin response. But food isn’t necessary for creatine to work.
With a small 2–2.5 gram dose, gastrointestinal symptoms are also less likely than with large loading doses. Consistency over time matters much more than whether creatine is taken at breakfast, after exercise or between meals.
That being said, we do pair creatine with food, most intentionally protein and carbs — for the greatest benefit.
What supplements to take with creatine: Magnesium, Potassium and MSG
Magnesium
Dr. Smith recommends in multiple YouTube livestreams that people increase their magnesium while taking creatine. He notes that muscle cramps can occur, potentially revealing an underlying need for more magnesium.
Learn more about how to dose magnesium here and which forms to take.
Potassium
Potassium helps maintain the sodium balance that supports creatine uptake, while also supporting proper hydration. (Learn how to supplement potassium here.)
MSG
Regarding MSG, read this article. We personally include all three of these supplements in our son’s creatine routine. MSG, in particular, helps maximize the benefits of our low-dose approach to creatine.
Creatine Quality Matters
Creatine monohydrate is chemically manufactured, and purity can vary according to the manufacturing and purification process.
Poorly controlled production can leave unwanted manufacturing by-products such as dicyandiamide (DCD), dihydrotriazine (DHT), creatinine and thiourea.
Much generic creatine is manufactured in China, but it would be inaccurate to assume that Chinese creatine is inherently contaminated. The important considerations are manufacturing controls, purification, testing and traceability.
One particularly well-documented (and recommended) option is German Creatine by Fitness Labs. It features Creapure®, manufactured in Germany. Creapure guarantees at least 99.9% purity, uses a dedicated manufacturing facility and tests individual batches for purity and unwanted by-products.
When choosing creatine, choose a product with a clearly identified source and meaningful purity testing. Products genuinely carrying the Creapure® seal provide unusually strong traceability.
I recently read the label of a friend’s creatine product that she thought was pure. In fact, it contained Vitamin D! Oral Vitamin D is a dangerous supplement to be avoided. Instead, our bodies need to make Vitamin D from light. Choose real sunshine, or in colder months, consider the safe use of tanning beds, inexpensive reptile lamps or a Vitamin D Lamp from Sperti.
Why did this unnamed creatine company add vitamin D to their “pure” product? Vitamin D may optimize muscle cells to more effectively pull creatine from your bloodstream. If you’d like to try out this theory, remember to get your Vitamin D from UV rays (not a synthetic hormone supplement).
What About Expired Creatine?
It might seem like a funny sub-topic, but a lot of people tried creatine briefly in the past, gave it up, and still have an old tub sitting in the back of a cupboard. If the product is clean, with only one ingredient …
Pure, dry creatine monohydrate is remarkably stable. Research indicates that powdered creatine can remain stable for years when stored properly.
Over time, creatine can degrade into creatinine, but degradation occurs much more readily after creatine is dissolved in liquid, especially acidic liquids and at higher temperatures.
An expired container that has remained sealed, cool and dry, with normal color, smell and appearance, is probably not only safe but just as effective as it was when created. Moisture, discoloration, unusual odors or evidence of contamination are reasons to discard it.
Do You Need to Cycle Creatine?
There is no established need to cycle on and off creatine. Research hasn’t demonstrated that the body develops a tolerance requiring breaks. However, it may be one additional way to give the kidneys a break. And this approach works well with creatine because creatine stores decline very gradually: No progress is lost through short breaks.
Periodic breaks could look like: 8–12 weeks on followed by 2–3 weeks off.
Muscle creatine stores decline gradually after supplementation stops, generally returning toward baseline over approximately 4–6 weeks. If restarting, there’s no reason to load again. Simply resume the normal low daily dose.
Summary
For someone who doesn’t need immediate muscle saturation, creatine supplementation can be remarkably simple: Skip loading and take a small amount consistently.
While 3–5 grams daily has the strongest research base, studies and earlier sports-nutrition guidance support benefits from doses around 2–3 grams daily as well.
A 2–2.5 gram daily dose of high-quality creatine monohydrate, without loading, therefore represents a reasonable conservative strategy — knowing that its effects will develop more gradually.
Loading, special carbohydrate drinks and excessive water consumption are not necessary for creatine to work. The fundamentals are much simpler: Choose a well-tested 1-ingredient clean product, take a modest/low dose consistently, and maintain normal adequate hydration.
Wow, it just got a whole lot easier to try creatine gently!
(By the way, I do not recommend anyone take creatine. This post is written for those who plan to take creatine and would like a gentler approach. Because it was important to my son to take creatine, I investigated the best and gentlest approach.)
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Steve Jonas says
Hi Megan,
Nice article on Creatine. A question that I have is about how soon to consume it when mixed with a liquid. I heard from one doctor that if creatine sits in a liquid for very long that it can become unstable not provide the potency or the pure creatine supplement. Any truth to that?
Thanks
Megan says
Hi Steve!, Yes, that’s true, and a great question and point for me to clarify: Creatine is very stable as a dry powder, but once dissolved in liquid, it can gradually break down into creatinine. This conversion happens faster in acidic liquids, at warmer temperatures and the longer the mixture sits, so it’s best to mix creatine shortly before drinking it. I leave the canister out at night for my son; when he wakes up, he mixes a scant 1/2 scoop into 12 ounces of water and drinks it right then, with his breakfast. Creatine can be taken any time of day, so taking it in the morning is easy, no matter when you time your workout.
Steve Jonas says
Thanks so much Megan! That is a great explanation, the best I have seen, and I thank you for that. If creatine sits in a liquid and turns into creatinine, is that a dangerous compound to consume then? How bad is creatinine?
Really appreciate you taking the time to respond. Appreciate you.
Megan says
So happy to help, Steve! 🙂 The biggest problem is that once creatine has converted to creatinine, you’re no longer getting the creatine you intended to take. Creatinine is a breakdown product and does not provide the same creatine/phosphocreatine benefits.
Creatinine is also a waste product that the kidneys must remove from the bloodstream. Orally consumed creatinine can be absorbed and raise blood creatinine. This gives the kidneys additional creatinine to filter and eliminate from the body, putting strain on the organ and possibly reducing its functionality.
Doctors use the amount of creatinine in your blood to help estimate how well your kidneys are filtering. Higher blood creatinine generally makes calculated kidney function (eGFR) look lower. So consuming creatinine could potentially raise the number for reasons other than actual kidney damage and show your kidneys to be functioning less efficiently than ideal.
For these reasons, it’s best to mix creatine shortly before drinking it rather than preparing it far in advance and allowing more of the creatine to break down into creatinine. If you have to mix it ahead of time, refrigerating it helps slow the conversion process. Better options are: Bring the powder, water and cup with you wherever you’re going, or, at home, mix it just before drinking. 🙂
Steve Jonas says
Hi Megan,
That is a very helpful answer to my question. I am going to have to change how we are consuming creatine as I have been putting it in our smoothies I make the night before taking them to work with us. From now on I will be mixing and drinking the creatine mixture right away. So very helpful info. Thank you so much!
Megan says
Wonderful, so glad it’s helpful!! My pleasure!
Sarah says
Fascinating article, Megan. Have not seen this information before now. I had a recipe for overnight oats with creatine… guess I won’t be making those! My brother gifted me some flavored creatine and I’d rather use it in yogurt than in water. Maybe a smoothie??
Megan says
Hi Sarah, thank you; I’m glad you enjoyed the article. Yes, your smoothie idea is a good one, with the yogurt, sounds good. I’m about to write an article about yogurts that you can watch for: It has similar surprising information about which yogurts are okay to eat, as most now use a starter, Streptococcus thermophilus, that turns into 13-cis-retinoic acid (the chemical name for Accutane/isotretinoin) in the gut. Nancy’s whole milk organic yogurt does not use this probiotic, nor do they use it in their kefir. I couldn’t find another yogurt in the store without it. Homemade yogurt is the other option, of course. Best!
Maiken says
Hi Megan,
I am interested in using Creatine for brain health. Do any of the studies you’ve read say whether the smaller dose of 2 gr. per day have the same effect for the brain? I’ve read from a practitioner that you need twice the recommended amount of 5 grams per day for muscles for it to reach the brain. So that would be 10 gr. per day! That’s quite a lot more, and now I’d be concerned for my kidneys.
Thanks,
Maiken
Megan says
Hi Maiken, good question. Unfortunately, there haven’t been studies using the smaller dosages to see how they affect brain health. I think you’re right to question the dangers of the higher dose on your kidneys, not worth the risk. It might be worth the experiment, though, to try the 2 grams per day, and see if you notice a benefit.
Maiken says
Thank you Megan. You always have something interesting to share and I appreciate all the research you do.
Megan says
My pleasure, Maiken, so kind of you, and I’m so glad it’s helpful.